Tag: 上海后花园

aqtifnwn

April 15 2016The construction crew has started to

first_imgApril 15, 2016The construction crew has started to work on the second set of stairs leading into the Colly Soleri amphitheater.[photos by Chihiro Saito, text by Sue Kirsch]Here is construction manager Ron Chandler making cuts into the concrete to help demolish the old stairs.Paolo Van Erp and Rachel Holderbach.Rachel. More to come.last_img

CONTINUE READING
dyekoypw

Camera maker GoPro has pledged to give up to US5

first_imgCamera maker GoPro has pledged to give up to US$5 million (€4.4 million) annually to content creators as part of its newly-launched GoPro Awards scheme.The firm said that the Awards programme will reward the GoPro community for sharing their best GoPro photos, raw video clips and video edits, with the company – which will include it in GoPro Channel programming, licensing and more.GoPro said it is looking for content that “emotionally engages, amazes, or excites” across a variety of genres including adventure, animals, family, motorsports, music and travel.“Our customers are some of the most creative people on the planet. A key component of our programming strategy is user generated content,” said GoPro founder and CEO Nicholas Woodman.“GoPro Awards creates exciting opportunities for our customers. Whether it’s helping them monetise their content in the form of financial rewards, helping to license their content to other businesses, or helping them get more exposure through our global social and media distribution channels, we’re dedicated to sharing with our community. We believe this program enables our customers to further pursue their passions.”GoPro launched an on-demand channel – consisting of GoPro-shot content – on the Roku streaming platform earlier this year and in July launched a content licensing portal, aimed at global advertising brands and agencies.last_img read more

CONTINUE READING
dyekoypw

If you were born between 1980 and the mid2000s W

first_imgIf you were born between 1980 and the mid-2000s, Wall Street probably hates you. It’s not because you’re a narcissist, entitled, or lack entrepreneurial spirit. And it has little to do with the fact that you haven’t opened a trading account to buy stocks. It isn’t even because you’re shunning high finance to pursue a “more meaningful” career. No, Wall Street dislikes you because you’re difficult to cash in on. If you haven’t guessed already, I’m talking about millennials—a cohort of Americans who are constantly being told how awful they are. Wall Street’s gripe with millennials is a big one. They represent one-third of the US population, making them the largest demographic in America. Yes, bigger than the baby boomers. Unlike prior generations, millennials are in no rush to grow up. Instead of making down payments on first homes, millennials are crashing in their parents’ basements. Rather than shopping at Walmart, they’re buying their groceries at farmers’ markets. This generation doesn’t buy cars. They use ride-sharing programs like Uber. The unique lifestyles and consumer preferences of millennials are frustrating Corporate America. McDonald’s is rewriting its menu and rethinking its marketing strategy to reach millennials, who would rather down a kale smoothie than stuff their faces with Big Macs. Say what you will about millennials, there’s no denying that they’re the future of America. The question that remains is: How do investors play a demographic that isn’t getting married, having children, or buying homes? The answer is technology. For better or worse, millennials are obsessed with their gadgets. Twenty-somethings can’t even take a bite of their sandwich without first snapping a picture of it. And those photographs of ramen bowls and steam buns aren’t being stored away as personal mementos. Millennials are broadcasting them on the Internet for everyone to see. But the key to “reaching” millennials isn’t through technology in a general sense. Social media is the ticket. According to Entrepreneur.com, 71% of millennials log in to social media daily, and the average user spends more than five hours on social media. This connection with—some would argue, addiction to—social media defines millennials. Unfortunately, that doesn’t make investing in this generation any easier. There are countless social media services out there. New ones pop up every day. Choosing the right company to invest in can be difficult, especially for investors who are still wary of Internet stocks following the tech bubble crash of the early 2000s. It doesn’t help that some social media companies are still stuck in start-up mode and have yet to generate a profit. Social media companies are tough to understand and even harder to value. Nonetheless, the industry has a bright future. Luckily, The Casey Report has done its research, and discovered a low-risk way to play one generation’s obsession. The best thing about this investment is that the money is just pouring in right now. Sign up for The Casey Report today to learn about this pick and other big-picture ideas.last_img read more

CONTINUE READING
dyekoypw

I made 17 trades during my first six weeks as a tr

first_imgI made 17 trades during my first six weeks as a trader. Every single one was a winner.Going 17 for 17 was a remarkable feat for a rookie trader—especially since I wasn’t using any sort of fundamental or technical analysis. I was just going with my gut.But I was careful not to put more than $1,000 or $2,000 into any single trade. And I still managed to turn my $5,000 brokerage account into $50,000 in just six weeks…And then I decided it was time to get serious. No more tiny trades. I was too good for the small stuff. For whatever reason, I had figured out a way to beat the market.Heck, I had just rattled off 17 straight triple-digit winners. So I decided to take the $50,000 in my account, add to it my $25,000 in savings, and put it into a handful of options trades.You can probably guess what happened next.The stock market has a habit of humbling folks who think they’ve figured it out. For me, the humbling started right away.At first, the positions started slightly moving against me. It was nothing to be concerned about. One good day would put everything back in the profit column.But then, one by one, each position blew up on me. It was too painful to watch. I kept the television off and avoided reading the newspaper for fear I’d see something bad about the stock market and my positions. — Geologist Uncovers Incredible Resource Opportunity in IdahoDave Forest, a professionally trained geologist, has visited over 23 countries, but one of his most stunning finds is here in America. Dave discovered a rare fuel source buried in the ground in Idaho that he calls “Brandt Oil,” and it could change the energy landscape in the U.S. for good… We’ve asked Dave to give you complete access to everything he’s uncovered about “Brandt Oil.” Just click here for details. Recommended Link When I finally got up enough courage to call the branch manager and check on the status of my account, I learned all the gains I had built up over the previous six weeks were gone.“Just sell everything,” I said.That was an expensive lesson to learn. But it’s one every options trader learns at some point. I was just fortunate it happened to me early in my career.You see, that experience changed how I looked at trading. Instead of using options as vehicles for speculation—a way to juice my returns and get more bang for my buck—I started using them the way they were intended to be used: as a way to reduce risk.Today, I still do my fair share of speculating. But I’m not focused on how much money I can make. I’m focused on how little I can lose.That’s a huge difference. It has allowed me to trade options successfully for nearly three decades. And it allowed me to retire at 42.Best regards and good trading,Jeff Clark Editor, Market MinuteP.S. Like any honest trader will admit, this is far from the only horror story that has occurred over my career. But my favorite story, which started out just as scary… ended quite differently.You see, I’d learned from my previous mistakes… and turned what was almost a devastating loss into one of the biggest wins of my career. Click here to hear all about it.Reader MailbagToday, another reader writes in about Doug Casey’s recent piece on the Alex Jones ban…Thanks Doug, for your comments about Facebook, Alex Jones and free speech. Makes me see this in a different light. —EdAs always, if you have any questions or suggestions for the Dispatch, send them to us right here.In Case You Missed It…Recently, President Trump signed an executive order that mandates the Interior Department begin mapping the country to locate America’s “Brandt Oil” reserves.“Brandt Oil” is a new, clean super fuel that’s so powerful, less than two gallons’ worth contains enough raw energy to power your house for nine years. So it’s no surprise “Brandt Oil” applications are going mainstream.Get the full story right here… Justin’s note: Regular readers know I read master trader Jeff Clark’s Market Minute every morning. It’s a quick way to see everything I need to know about the coming day’s market action… and get expert trading advice—for free.Today, I’m sharing one of my favorite essays from him. If you’re interested in becoming a better trader, the following essay is required reading. In it, Jeff shares one of the most important lessons of his career…By Jeff Clark, editor, Market MinuteI was only 19 years old when I made my first options trade.I had a gut feeling the market was going to go higher… so I bought four S&P 100 call options at $1.50—a total investment of $600. A few hours later, the options were trading at $4.50. I sold and took the $1,200 profit—a 200% gain. And I was hooked on options forever.My next trade was in IBM. I bought 10 calls for $1. This time, it took a couple days to double my money. Next, I bought Digital Equipment put options… which nearly tripled in just a few days. This Illinois Farmer Made $2.5 Million (so can you)He didn’t touch stocks or bonds. The profit wasn’t from his farm, either. Rather, it’s from an idea Ronald Reagan had wanted all Americans to have. Recommended Link —last_img read more

CONTINUE READING
dyekoypw

Walter Mischel a revolutionary psychologist with

first_imgWalter Mischel, a revolutionary psychologist with a specialty in personality theory, died of pancreatic cancer on Sept. 12. He was 88. Mischel was most famous for the marshmallow test, an experiment that became a pop culture touchstone. But, he said, the thrust of the experiment and its results were often misinterpreted. (You can hear Mischel explain why in the video by Marcie LaCerte at the top of this page).Born in Vienna in 1930, his family fled to the United States when Mischel was only 8 years old. After graduating from New York University with bachelor’s and master’s degrees in psychology, he went on to get a Ph.D. from the Ohio State University in 1956. Mischel’s education left him frustrated with the orthodox research models of the time, many of which were influenced by the likes of Freud. Mischel believed these models failed to adequately consider context, both the particular experimental situation and people’s internal goals. So, he set out on different path in 1960, using preschoolers from Stanford University’s Bing Nursery School as his study subjects. His idea, which you’ve probably heard of, was simple enough. First, you sit a kid in front of a delicious marshmallow. Then, you tell her she will get two marshmallows if she can resist eating the marshmallow while you leave the room. His experiment was a test of delayed gratification and, over the years, the test epitomized the idea that there are specific personality traits that we all have inside of us that are stable and consistent and will determine our lives far into the future. Despite some follow-up studies that failed to replicate the results, the lesson our society has drawn from the marshmallow test is that children who are able to delay their own gratification are destined to be more successful as adults than those that can’t. There was just one problem with that conclusion, as Mischel himself explained to Alix Spiegel, in an episode of the podcast Invisibilia called “The Personality Myth.” He told her: “That iconic story is upside-down wrong — that your future is in a marshmallow — because it isn’t.” So why does this myth seem to persist? Well, it seems one crucial detail was left out of conversation. Some kids were given strategies to help them resist the tempting treat, such as closing their eyes, while others were not. And, it was the kids who were best at deploying these strategies who had greater success in later life. “People can use their wonderful brains to think differently about situations, to reframe them, to reconstrue them, to even reconstrue themselves,” Mischel said.Nearly fifty years after the publication of his early iconic work, Mischel was still on the forefront of correcting the entrenched orthodoxy of static personalities, as well as the psych myth that his famous study had become. In 2014, he wrote The Marshmallow Test: Mastering Self-Control. “What my life has been about is in showing the potential for human beings, to not be the victims of their biographies — not their biological biographies, not their social biographies,” he said. “And to show, in great detail, the many ways in which people can change what they become and how they think.”Julie Carli is an intern with Invisiblia. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

CONTINUE READING
dyekoypw

Starting Wednesday the sale of recreational marij

first_imgStarting Wednesday, the sale of recreational marijuana begins in Canada following a law passed over the summer.The law says anyone in Canada over the age of 18 is allowed to possess marijuana, provided it’s less than 30 grams — just over an ounce. Canadians can also grow up to four marijuana plants in their home and buy from a provincially regulated retailer.The country had months to prepare for the law’s launch. The House of Commons and the Senate approved legalization in June, and later scheduled the law to go into effect on Wednesday.Keeping the drug illegal in the years prior “has allowed criminals and organized crime to profit, while failing to keep cannabis out of the hands of Canadian youth,” the government said in a news release last year. The Canadian Department of Justice says historically, the majority of police-reported drug offenses have involved marijuana.The government of Canada will oversee production and manufacturing of the drug. Provincial and municipal governments have control over wholesaling, and will also be able to set laws on public consumption. In provinces without a regulated retail framework, Canadians can purchase marijuana online from a federally licensed producer with “secure home delivery.””Provinces will learn from each other, municipalities will learn from each other,” former Deputy Prime Minister Anne McLellan told Here and Now in September.McLellan added that early tax revenues from generated cannabis sales will be used to research addiction treatment, for mental health resources and treatment, and for public education about the drug. “We heard when we visited states in the U.S. that have legalized [marijuana], it’s really important to get out and educate your public,” she said. McLellan said the government’s early estimates of use in the country of 36 million ranges from 650,000 to 900,000 tons on an annual basis. A report by Deloitte estimates the Canadian marijuana market will pass $7 billion by 2019.”I do believe that the government of Canada is ready,” McLellan said.Prime Minister Justin Trudeau told reporters last week that he would look into pardons for Canadians convicted of cannabis possession. Prior to the new law, simple possession of the drug was punishable by fines of up to $1,000 and six months in prison.Canada is only the second in the world to legalize recreational use of the drug. Uruguay became the first in 2013. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

CONTINUE READING
dyekoypw

First AfricaDesigned Smartphone Elikia Goes On Sale In Congo

first_imgVMK’s Elikia, which means ‘hope’ is priced at about $171 Advertisement VMK’s Elikia, which means ‘hope’ is priced at about $171Congolese gadget manufacturer, VMK, has began selling Elikia, Africa’s first home-grown designed smartphone, in Congo, in what has garnered international attention.The increase of consumer purchase, and the need to close the technological gap in Africa has driven an influx of tech giants including RIM, Huawei, Techno, and Apple, into the continent.In 2009, VMK committed itself to giving Africans affordable access to technology in the mobile business where Africa is said to be comparatively behind. – Advertisement – Elikia, which means ‘hope,’ is priced at 85,000 FCFA ($171) by two major telecom operators in Congo – Airtel and Warid, and has a 650 MHz processor, running gingerbread 2.3.6 with 128 MB of on-board storage.iPhone 4, an older Apple smartphone model, costs around $450 on the continent, though the device comes with enhanced features.According to  VMK, it would launch a $50 tablet for students mid next year, in the continuous bid to provide affordable mobile technology to Africans.Verone Mankou, the start-up’s founder, says he plans to make a dominant share of the African market use the Africa-designed smartphone and tablet VMK is producing, so that the company can be to Africa what Apple is to the U.S. and Samsung is to Asia.The start-up’s mission however, is a long haul. For instance, Nigeria, one of the largest smartphone markets in Africa, is a 4 million smartphone market volume, with over 50 percent dominated by Canadian manufacturer, Research in Motion (RIM).VMK’s first product is the Galaxy tab-sized tablet called Way-C, meaning ‘the light of the stars.’ It now sells for $300.Elikia can also be bought within the confines of the French Institute of Congo (IFC). Other regions in Congo will follow suit in the coming days.By January 2013, the pan-African company will begin international marketing for the device.Credit: Ventures-Africalast_img read more

CONTINUE READING
dyekoypw

Mediafly Unveils New Sales Enablement Platform Experience for the Future of Evolved

first_img B2B buyerscontent managementMarketing TechnologyMediaflyNewsSales enablement technologySAP App Center Partner Previous ArticleGlobal Customer Adoption Accelerating for 8×8 Contact Center SolutionNext ArticleFor Highly Reputable Senders, 91 Percent of Emails Reach Their Intended Audience—Compared to 70 Percent or Less for All Other Senders Mediafly, a provider of sales enablement technology, content management, and advisory services that create interactive, value-based selling experiences, presents a brand new platform interface and added functionality to meet the needs of sellers across the globe. In addition to the updated user experience, new capabilities include Mediafly Workspaces, Story Mapper and Tool Builder, which provide users the ability to customize in-app experiences on their own, without incremental coding resources, including designing custom ROI calculators. As part of the new platform experience, Mediafly is introducing a new iOS app – Mediafly Next.While companies have the best intentions when unveiling new sales enablement solutions, many of these deployments fail. According to one study, U.S. organizations wasted $30 billion on unused software over the course of four years. Often times, this is due to technology not meeting the expectations of its users. For sellers, lack of customization and legacy solutions leave them scrambling to find relevant content and value-based evidence to provide the personalized sales interactions that modern buyers require. Admins and leaders of these teams are left to figure out how to design and organize the information that sellers need to succeed. Unfortunately, for many organizations, the process of designing an intuitive presentation app experience with interactive content that gains positive feedback and ultimately, a purchase, requires an unrealistic investment of time and budget.“Sales enablement technology should be flexible, easy to use and allow for customization,” said Jason Shah, CTO at Mediafly. “Our customers want to personalize their solutions so they can provide the best experience to their buyers. With the new Mediafly, users can continue to feel well equipped in their sales conversations, providing value to their buyers at a faster rate, helping to increase revenue and exceed quotas.”Marketing Technology News: ON24 Empowers Marketers with a 360-degree View of Customer EngagementTo help sales teams evolve from traditional content management portals and presentation tools like PowerPoint and guide them on how to improve sales, Mediafly gives users access to a modern, sophisticated, consumer-like presentation app experience across desktop and mobile. Now admins and sales reps can easily self-author and experience an interface with animations, customizable layouts and navigation, and interactive content without added support from Mediafly or IT.Mediafly’s release includes three new capabilities: Mediafly Workspaces, Story Mapper and Tool Builder. With Workspaces, admins have the power to create a mobile presentation interface with the navigation and content they want the sales teams to leverage, and sellers can find the content they need with ease for their unique sales presentation. Through Story Mapper, sellers can instantly pivot to relevant content in their presentation to better address buyers needs and questions. This allows them to create buyer-focused conversations through an interactive and value-add interaction.Value-add experiences are increasingly important as B2B buyers become more budget restrained and risk-averse. In fact, six in 10 buyers want to discuss pricing on the first call. Mediafly’s Tool Builder gives sellers the flexibility to customize interactive tools such as ROI and TCO calculators in an easy-to-use environment, saving the user time and energy. Sellers can provide buyers with meaningful value messaging, compelling insights and credible financial justification that is unique to that specific buyer in every sales conversation.Marketing Technology News: Vyond Announces End of Beta for Vyond Studio, Enhanced Security Features“Since we started using Mediafly, our customers have rated their experience higher, citing things like the ability of reps to give them the best information in the moment,” said Tom Stubbs, Sales Capability Communications Manager at PepsiCo. “Mediafly gives us the ability to design a modern sales experience customers value.”Mediafly’s latest sales enablement technology updates are just a few of the ways Mediafly helps sellers and marketers create, deliver, and analyze engaging sales presentations. Mediafly’s continued focus on enhancing how brands engage prospective buyers was recently recognized by G2. The sales enablement platform was named a Leader in G2’s Spring 2019 Grid Report for Sales Enablement. The grid, which is based on customer satisfaction and market presence, highlights that 96 percent of Mediafly users rated the platform 4 or 5 stars and 90 percent of users would recommend Mediafly’s platform. Additionally, Mediafly was recognized as a SAP Finalist for SAP App Center Partner of the Year. The award recognizes SAP partners with world-class solutions, contributing a significant amount to SAP revenue, a solid track record of customer success and a solid business plan for continued partner success.Marketing Technology News: Malicious and Disruptive Ads Account for 1 in Every 100 Impressions According to New Confiant Research Mediafly Unveils New Sales Enablement Platform Experience for the Future of Evolved Selling MTS Staff WriterMay 23, 2019, 4:55 pmMay 23, 2019 last_img read more

CONTINUE READING
dyekoypw

Centro Releases Universal Pixel for Easy Creation and Management of FirstParty Audiences

first_imgNow Available in Centro’s Basis Platform to Automate Tracking and Measurement of AudiencesCentro, a global provider of advertising technology, announced the launch of universal pixel on its comprehensive platform, Basis. Universal pixel technology uses a single pixel to automate the creation and organization of first-party audiences, eliminating the need for multiple audience and conversion pixels.This new Basis feature makes it easier and faster for advertisers to measure conversions and track customer actions. Beta tests show that media buyers are upping performance and saving time using universal pixel to segment and group customers into categories based on their actions within a domain.Basis is the industry’s most automated, comprehensive and intelligent digital media platform, converging planning, buying, operations, campaign analytics, business intelligence, and billing reconciliation. No other DSP combines high-grade programmatic advertising features with holistic media workflow technology. Basis seamlessly assembles the tools that media businesses need to move towards full automation.Marketing Technology News: DAA Announces Enforcement Deadline for ‘Political Ad’ Guidelines and Transparency Icon“As the steward of top tier brands, we have an enormous responsibility to drive KPIs for clients and do it with efficiency,” said Matt Mordarski, senior digital media specialist at Perich Advertising + Design. “Automating our business through Basis already gives us an edge in the market. Now we are capitalizing on new tools such as universal pixel to enhance the tracking of first-party audiences and increase the agility of our team.”“With our campaigns, we are continually measuring and improving upon our performance. Generating and managing pixels is an essential part; but until now, it has been a tedious and lengthy process. Having the ability to use only one pixel to create various models for targeting, attribution and subsequent optimization makes us more efficient while improving ROI for our clients,” said Jessica Behal, founder of Spherical Strategies. “Since using universal pixel in tandem with the full agency toolset in Basis, we have seen considerable improvements in campaign performance.”Traditionally, marketers have had to use multiple pixels to create first-party audiences and track unique actions from site visitors. This meant hours of work to create many pixels, coordinate placement, and verify deployment. Thanks to the introduction of universal pixel, that work has been eliminated.Marketing Technology News: SentinelOne Announces $120 Million Series DAs marketers’ needs change, they use Basis to modify the data a universal pixel gathers. One pixel has the capability to segment audiences based on any combination of actions they take (search, click, browse, convert, etc.). Any number of combinations can be assigned to a single pixel.“Universal pixel illustrates how digital media automation is realized, as it improves a typically laborious process of tracking how customers interact with a brand. Its impact on campaigns ranges as far as the creative thinking of the media team,” said Tyler Kelly, president, Centro. “With this feature seamlessly implemented in Basis, our customers have more capabilities that save time, reduce human error, and are easy to use.”Marketing Technology News: New Global Report Reveals 9 in 10 Companies See ‘Self-Service’ as the Future for Customers Centro Releases Universal Pixel for Easy Creation and Management of First-Party Audiences Globe NewswireJune 13, 2019, 6:51 pmJune 13, 2019 advertising technologyCentroMarketing TechnologyNewsPerich Advertising + DesignTyler Kellyuniversal pixel Previous ArticlePipelineDeals Launches the Women in Tech ScholarshipNext ArticleReelTime VRs New ReelTime Virtual Room May Be Coming to a Hotel or Home Near Youlast_img read more

CONTINUE READING
dyekoypw

Celprogen successfully prints 3D Brains from brain stem cells to study neurological

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 1 2018Celprogen Inc., a leader in the Stem Cell Research and Therapeutics industry for stem cell research since 2002, today announced that they have successfully finished printing 3D Brains from brain stem cells for studying neurological disease stages. The poster on this work will be presented at the Annual Neuroscience meeting in San Diego, Nov 3rd 2018. The 3D printed human brain was utilized for studying “The role of Microglia activation and deactivation in neurological diseases.” Celprogen has been able to identify and characterize 11 lead compounds that are potential drug candidates for Alzheimer’s, Parkinson’s and Glioblastoma patients.The present invention relates to 3D organ printing programs at Celprogen that identifies potential future use in transplant of major organ systems. At present, Celprogen is validating the 3D human printed heart, pancreas, liver, hair follicle and brain for toxicology and drug discovery research. Source:http://www.celprogen.com/last_img read more

CONTINUE READING
dyekoypw

Multidisciplinary team successfully performs complex surgery on patient suffering from enlarged skull

Dec 14 2018A 2-year-old girl with an extreme form of hydrocephalus could someday lead a more normal life, thanks to a remarkable surgical intervention aided by state-of-the-art technologies used by a leading pediatric team supervised by two assistants professors of medicine at Université de Montréal.The child, who underwent two operations at CHU Sainte-Justine children’s hospital in Montreal, including a total cranial vault reconstruction, could not even sit upright because of the size and weight of her head. Her brain was being compressed by an excess of cerebrospinal fluid.Related StoriesHome-based support network helps stroke patients adjust after hospital dischargeTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’Study: Two-thirds of pneumonia patients receive more antibiotics than they probably needUsing virtual modelling and three-dimensional technology supported by a 3D printer, and after a 12-hour operation, surgeons were able to open the child’s abnormally large skull and reconstruct it to closer to normal dimensions. Prior to the procedure, her skull contained three litres of cerebrospinal fluid, while the normal amount is 150 millilitres. To achieve this amazing feat, the team made a detailed model of the girl’s skull, numbering the sections so they could later put them back in place, somewhat like a puzzle.”Our little patient suffered from an enlarged skull, otherwise known as extreme macrocrania,” said Dr. Alexander Weil, a pediatric neurosurgeon (MD, FRCSC, FAANS, FACS) at CHU Sainte-Justine. “If we hadn’t operated, she would have continued to be weighed down and immobilized by the size and weight of her head. This surgery gives us hope that she will now be able to develop and live more normally.” Added Dr. Daniel Borsuk, the hospital centre’s head of plastic surgery (MD, MBA, FRCSC, FACS): “The collaborative efforts of an experienced multidisciplinary team, which made it possible to successfully carry out this complex surgery.”The surgeons expressed their heartfelt thanks to all the health professionals who took part, as well as to the child’s family for placing their trust in the medical team. Source:https://www.umontreal.ca/ read more

CONTINUE READING
dyekoypw

Galectins play a key role in the degeneration of cartilage in osteoarthritis

first_img Source:https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-dezember-2018/network-of-proteins-influences-the-advancement-of-osteoarthritis/ Reviewed by James Ives, M.Psych. (Editor)Dec 19 2018A network of carbohydrate binding proteins – so-called galectins – plays an important role in the degeneration of cartilage in osteoarthritis. A research group at the MedUni Vienna was able to demonstrate this correlation, in cooperation with international study partners. In osteoarthritis, certain galectins are produced by the cartilage cells themselves and accelerate the degeneration process of the cartilage matrix.Whilst galectins do play a role in cartilage development during childhood growth, they essentially do not occur in healthy adult cartilage. The researchers working with Stefan Tögel from the Department of Orthopedics and Trauma Surgery at the MedUni Vienna/Vienna General Hospital have now discovered that the quantity of galectin-8 found in the cell samples was correspondingly greater with an increasing severity of cartilage degeneration. After its production, this protein is released by the cartilage cells and connects with the cell surfaces, where it causes inflammatory processes and accelerates the matrix degradation of the cartilage tissue. Other galectins, which are otherwise able to perform various functions in the cell, apparently also play an accelerating role here.Research in the field of glycobiologyIn previous studies, Stefan Tögel’s research group has succeeded in demonstrating for the first time the functional significance of glycobiology for the pathogenesis of osteoarthritis, and has identified galectin-1 and galectin-3 as being inflammation accelerators. Glycobiology essentially describes the structure and function of glycans (sugar chains), which are able to influence a broad spectrum of biological processes through interaction with carbohydrate binding proteins (e.g. galectins).Related StoriesGlucosamine supplements could benefit the heartResearchers report new regenerative medicine approach for treating osteoarthritis of the kneeNew type of treatment for osteoarthritis shows promise for use in humans”Our approach in researching the role of glycobiology in osteoarthritis and other degenerative cartilage diseases is very new”, explains Stefan Tögel. “We are essentially treading new ground with our studies.” The aim is new therapy approaches in the treatment of osteoarthritis, which will halt its advancement. Because once cartilage tissue is lost, it can no longer be regenerated. For this purpose, it could be possible to develop antagonists for the respective galectins, which will prevent them from attaching to the cell surfaces. “Galectins may also be suitable as biomarkers, which will enable an early diagnosis through a blood test or with a sample of the synovial fluid”, explains Tögel.Osteoarthritis – a widespread diseaseOsteoarthritis is a degenerative joint disease, which leads to a change in the structure of cartilage and bone, and can even result in joint deformity. It usually results from many years of over-straining. Joint diseases are among the leading causes of chronic pain and immobility in old age, and constitute a serious socio-economic factor in the health sector due to the increasing life expectancy of the population. No treatment has been available to date, which could halt the progressive loss of cartilage tissue in an osteoarthritic joint, or even reverse this.last_img read more

CONTINUE READING
dyekoypw

Higher coronary artery calcium levels in middleage linked to increased risk for

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 16 2019Higher coronary artery calcium levels in middle-age were associated with structural heart abnormalities linked to future heart failure, particularly among blacks, according to new research in Circulation: Cardiovascular Imaging, an American Heart Association journal.Coronary artery calcium (CAC) is the buildup of calcified plaque made up of fat, calcium and cholesterol. The calcium found in this type of plaque is not related to dietary calcium. Elevated cholesterol levels in the blood can contribute to plaque buildup, known as atherosclerosis, which narrows the channel within an artery and reduces blood flow.CAC is a risk marker for heart health problems, and CAC screening was added to the American Heart Association’s 2018 cholesterol management guidelines to further improve early detection of heart health abnormalities, especially among people who might be at a higher risk. A CAC score of zero indicates there is low risk in the absence of other high-risk conditions, while a score above zero indicates increasing risk.In this study, researchers tracked 2,449 people (52% white, 57% women) from young adulthood to middle-age. Non-invasive computed tomography imaging tests were used to gauge the participants’ vascular health, with participants’ imaging tests and CAC scores compared at years 15 and 25 of the study period.By year 25, participants’ average age was about 50. Seventy-two percent of the group had a CAC score of zero compared with 77% a decade earlier. Moreira and team found that increases in CAC scores were independently related to increasing age, male sex, black race, higher systolic blood pressure, higher total cholesterol, diabetes mellitus and current smoking, as well as the use of medications to lower blood pressure and cholesterol. Additionally, they found: Related StoriesImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsStudy explores role of iron in over 900 diseasesWeightlifting is better for the heart than cardioBlacks already face a greater risk and burden of heart disease and stroke: 60% of adult black men and 57% of adult black women have some form of cardiovascular disease, compared with 50% of white men and 43% of white women.”Racial differences in our findings may be due to genetic factors or perhaps greater exposure to cardiovascular risk factors that usually appear earlier in blacks,” Moreira said. “We need more research to examine the link between coronary artery calcium and heart health.””Prior studies have shown that presence of CAC and higher CAC scores are associated with atherosclerotic cardiovascular disease in young to middle aged adults. The results of this study are important as they highlight that presence of CAC and higher CAC scores may also be associated with echocardiographic markers of subclinical LV systolic and diastolic dysfunction,” said Salim Virani, M.D., a member of the writing committee for the American Heart Association’s 2018 cholesterol guidelines and director of the Cardiology Fellowship Training Program at Baylor College of Medicine in Houston. “Given the burden of morbidity and mortality associated with heart failure, these are important findings. Prior studies from this cohort have also shown that a better risk factors profile in young adulthood is associated with much lower CAC and therefore, these results further highlight the importance of primordial prevention and risk factor modification in early adulthood.”Source:American Heart AssociationJournal reference:Moreira, H.T. et al. (2019) Coronary Artery Calcium From Early Adulthood to Middle Age and Left Ventricular Structure and Function. Circulation: Cardiovascular Imaging. doi.org/10.1161/CIRCIMAGING.119.009228. Compared with patients who had CAC scores of zero, those who had higher CAC scores at middle-age had a 12% increase in left ventricular mass and a 9% increase in left ventricular volume, independent of other risk factors including demographic information and cardiovascular risks. Abnormalities in the left ventricle means the heart had to work harder to effectively pump blood, and as a result, became enlarged and thickened, a risk factor for heart failure. These findings were even more significant among blacks. For every one-unit change in a CAC score, blacks had four times higher increase in left ventricular mass compared with whites. While progression in CAC over the follow-up was strongly related to higher left ventricular mass in blacks, this relationship was not significant in whites. We looked at early adulthood to middle-age because this is a window in which we can see abnormalities that might not be causing symptoms, but could later increase the risk of heart problems. Prevention and control of these abnormalities are key, so early identification of risks can be crucial.”Henrique Turin Moreira, M.D., Ph.D., study co-author and an attending physician at Hospital das Clínicas de Ribeirão Preto at the University of São Paulo in Brazillast_img read more

CONTINUE READING
dyekoypw

Daily outdoor activity reduces progression of nearsightedness in children

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 25 2019New research suggests that adding 30 minutes of daily outdoor activity reduces the progression of nearsightedness, called myopia, in children if the activity is continued. The study, conducted by researchers in Beijing, China, is published in the May 2019 issue of Translational Vision Science & Technology (TVST).Myopia is recognized as a major public health issue in East Asia, particularly in China, and is expected to affect half of the world’s population by 2050, according to a 2016 study out of the Brien Holden Vision Institute. Evidence shows that severe myopia increases the risk of developing glaucoma or a detached retina, diseases that can lead to vision loss. Myopia is caused by the lengthening of the eye, which impacts how light is bent when entering the eye and, as a result, affects vision.Related StoriesWhy Mattresses Could be a Health Threat to Sleeping ChildrenNew network for children and youth with special health care needs seeks to improve systems of careChaos in the house and asthma in children – the connectionScientists, led by Dr. Yin Guo of the Tongren Eye Care Center, Beijing Tongren Hospital at Capital Medical University, studied 382 children ages 6 and 7 at two Beijing-area schools for one year in a prospective interventional study. Students in the study group jogged for 30 minutes outdoors daily. The control group did not add this extra outdoor activity to their schedules.Examinations at the end of one year showed that students in the study group without myopia at the baseline had lower incidence of myopia compared with students in the control group. Students with myopia at baseline also showed slower progression of myopia compared with students in the control group. Annual follow-up exams following the conclusion of the one-year study showed that in year four, incidence of myopia was similar among the study and control groups. Our research provides further evidence and confirmation of an association between increased outdoor activity and decreased prevalence and incidence of myopia. This study also indicates that increasing outdoor activity may delay the progression of myopia for up to two years. We now need to translate these findings into action among children in China and around the world in order to help preserve their vision.”Dr. Yin Guo of the Tongren Eye Care Center The authors also indicate that their results could have implications for how China and other countries structure childhood outdoor activity levels to combat the increasing incidence of myopia and its progression.This latest study on myopia and activity in children adds to a growing body of scientific research on this topic. Additional studies were presented at the ARVO 2019 Annual Meeting in Vancouver, BC, pointing to increased contact with man-made and indoor environments as potential causes of myopia. Additional information on myopia research is available in a February 2019 special issue of IOVS, International Myopia Institute (IMI) White Papers. Source:Association for Research in Vision and Ophthalmology (ARVO)Journal reference:Guo, Y. et al. (2019) Outdoor Jogging and Myopia Progression in School Children From Rural Beijing: The Beijing Children Eye Study. Translational Vision Science & Technology (TVST). doi.org/10.1167/tvst.8.3.2last_img read more

CONTINUE READING
dyekoypw

Selflearning assistance system for efficient processes

first_imgSAM, a self-learning assistance system, helps machine operators resolve errors in production machines. Credit: Fraunhofer IVV To take a concrete example: On a processing machine, chocolate bars are wrapped in paper. A sensor detects a deviation in the production process and the machine stops. Even with state-of-the-art systems, a brief interruption occurs on average every five minutes. An experienced machine operator knows where the cause of the error lies. He or she sees that the paper is bending and concludes that, in this case, the speed of the machine needs to be regulated. However, this knowledge is person-specific – a colleague with less experience would need more time to find the solution.To make this experience-based knowledge available to all operators at all times, scientists at Fraunhofer IVV in Dresden are developing SAM, a self-learning assistance system for machine operators. The system observes machine states and operator actions and saves successful solution strategies. Using a tablet computer, for example, the machine operator inputs his/her solution and then links it to the current fault situation recorded by SAM. If a given fault has occurred several times, SAM recognizes it and can give the operator tips on the cause and on how to solve the problem. In this way, the machine is quickly repaired and running again.To enable SAM to learn fault situations, the scientists at Fraunhofer IVV are using machine learning algorithms. Equipped with intelligent feature extraction, SAM is able to learn at a similar speed as humans and can recognize patterns after only a few repetitions. “Thanks to our knowledge of packaging machine processes, we’re able to make SAM very fast,” explains Andre Schult, Group Manager for Digitalization and Process Efficiency at Fraunhofer IVV.Working with SAM is a people-centered experienceWhen designing SAM, Fraunhofer IVV in Dresden put people at the center of their considerations. “A human being is a wonderful tool. With their hands and eyes, they are more flexible and better than many robots or cameras,” says Andre Schult. However, processes and systems are growing in complexity all the time. With SAM, Schult also wants to enable operators in the future to recognize errors themselves and suggest their own solutions. People should know that, despite all the state-of-the-art technology, humans play an indispensable role in production. This increases their sense of value in their work and their motivation.Together with partners from industry and science, Fraunhofer IVV plans to further develop the self-learning operator assistance system over the next five years and add new functionalities through a range of new modules. In this way, it will be possible to adapt SAM to specific customer requirements. Possible additional features include things like the use of image processing, external sensors, and speech and gesture recognition. Looking forward, manufacturers will be able to use SAM both for the operation and for the maintenance, setup, assembly and development of machines. Explore further Citation: Self-learning assistance system for efficient processes (2018, June 1) retrieved 18 July 2019 from https://phys.org/news/2018-06-self-learning-efficient.html To prevent long downtimes and high quantities of scrap, manufacturers must design production processes to be stable and efficient. Particularly successful outcomes are achieved when the experience of the people who operate the machines is taken into account. The Fraunhofer Institute for Process Engineering and Packaging IVV in Dresden is developing a self-learning assistance system that helps machine operators resolve errors and build up their experience and process knowledge.center_img Provided by Fraunhofer-Gesellschaft Better quality control with digital assistance systems This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

CONTINUE READING
dyekoypw

New Zealand plans new tax for giants like Google Facebook

first_img Explore further New Zealand’s government plans a new tax targeting online giants like Google and Facebook that earn plenty of money in the country but pay little tax. This July 19, 2016, file photo shows the Google logo at the company’s headquarters in Mountain View, Calif. New Zealand’s government announced plans on Monday, Feb. 18, 2019, for a new tax targeting online giants like Google and Facebook that earn plenty of money in the country but pay little tax. Prime Minister Jacinda Ardern said there’s a gap that needs to be closed. (AP Photo/Marcio Jose Sanchez, File) New Zealand halts Huawei from 5G upgrade over security fears © 2019 The Associated Press. All rights reserved.center_img Prime Minister Jacinda Ardern said there’s a gap that needs to be closed.”Our current tax system is not fair in the way that it treats individual taxpayers and the way that it treats multinationals,” she said. “It’s not fair.”She said the proposed digital services tax would tax multinational online companies at about 2 or 3 percent on the revenue they generate in New Zealand, a rate that is in line with other countries considering similar taxes.Revenue Minister Stuart Nash said foreign online companies have a competitive advantage over local companies that do pay significant amounts of tax. He said the new tax that was announced on Monday could be implemented next year.Nash said New Zealand would continue working with the Organization for Economic Cooperation and Development, or OECD, to find an international solution to the problems of taxing big online companies, but that New Zealand was not going to wait around.”The OECD can move at a rather slow rate,” he said.New Zealand’s government estimates that online multinationals do about 2.7 billion New Zealand dollars ($1.9 billion) worth of business in the country each year, and that the new tax could generate up to 80 million New Zealand dollars ($55 million) annually.The most recent New Zealand company filings indicate Google paid NZ$392,000 in income taxes in the 2017 calendar year. The company, which declined to comment, claimed a NZ$1 million loss over the year after booking much of its revenue in other countries.The last publicly available figures from Facebook show the company paid NZ$43,000 in taxes in New Zealand in 2014.Facebook said in a statement that it complies with applicable tax laws in New Zealand and every other country in which it operates. It said it’s moving to a “local selling model” to provide more transparency to governments and policy makers.Amy Adams, the finance spokeswoman for the conservative opposition National Party, said the party agrees that multinationals should pay their fair share of taxes but that it supports the OECD work being ramped up. She said New Zealand will find it difficult to go out on its own without people missing out on what the global market has to offer. Citation: New Zealand plans new tax for giants like Google, Facebook (2019, February 19) retrieved 17 July 2019 from https://phys.org/news/2019-02-zealand-tax-giants-google-facebook.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

CONTINUE READING
dyekoypw

Egypt opens Sneferus Bent Pyramid in Dahshur to public

first_imgDAHSHUR, Egypt (Reuters) – Egypt opened to visitors on Saturday the “Bent” Pyramid built for pharaoh Sneferu, a 101-metre structure just south of Cairo that marks a key step in the evolution of pyramid construction. An archeological worker displays a sarcophagus that was discovered near the King Amenemhat II pyramid, south of Cairo, Egypt, July 13, 2019. REUTERS/Mohamed Abd El GhanyTourists will now be able to clamber down a 79-metre (86 yards) narrow tunnel from a raised entrance on the pyramid’s northern face, to reach two chambers deep inside the 4,600-year-old structure. They will also be able to enter an adjoining 18-metre high “side pyramid”, possibly for Sneferu’s wife Hetepheres, opened for the first time since its excavation in 1956. The “Bent” Pyramid is one of two built for Fourth Dynasty founding pharaoh Sneferu in Dahshur, at the southern end of the Memphis necropolis that starts at Giza. Its appearance is unusual. The first 49 metres, which have largely kept their smooth limestone casing, are built at a steep 54 degree angle, before tapering off in the top section. The angular shape contrasts with the straight sides of Sneferu’s Red Pyramid just to the north, the first of ancient Egypt’s fully formed pyramids and the next step towards the Great Pyramid of Giza. Architects changed the angle when cracks started appearing in the structure, said Mostafa Waziri, secretary general of Egypt’s Supreme Council of Antiquities. “Sneferu lived a very long time…the architects wanted to reach the complete shape, the pyramid shape,” Mohamed Shiha, director of the Dahshur site, said. “Exactly where he was buried — we are not sure of that. Maybe in this (Bent) pyramid, who knows?” Authorities are seeking to promote tourism at Dahshur, about 28km (17 miles) south of central Cairo. The site lies in the open desert, attracts just a trickle of visitors, and is free of the touts and bustle of Giza. As they opened the pyramids, archaeologists presented late-period mummies, masks, tools and coffins discovered during excavations that began near the Dahshur pyramids last year and are due to continue. “When we were taking those objects out, we found…a very rich area of hidden tombs,” Waziri said. The promotion of Dahshur is part of a wider push to boost tourism, an important source of foreign revenue for Egypt that dipped steeply after the country’s 2011 uprising before gradually recovering. Archaeologists also unveiled the nearby tomb of Sa Eset, a supervisor of pyramids in the Middle Kingdom, which has been closed since its excavation in 1894 and contains finely preserved hieroglyphic funerary texts. Foreign ambassadors invited to attend the archaeological announcements were led sweating into the tight spaces of the tomb, which is not expected to be opened to the public for another two years. Our Standards:The Thomson Reuters Trust Principles.last_img read more

CONTINUE READING
dyekoypw

Telangana theatres to sell refreshments at MRP from Aug 1Telangana theatres to

first_imgSHARE July 30, 2018 prices, inflation and deflation COMMENT Violations to attract fines, jail term There is good news for cinema-goers in Telangana. Beginning August 1, food items and beverages sold in cinema theatres will be available at MRP (maximum retail price). The Legal Metrology will slap heavy penalties on those selling refeshments over and above the MRP.First-time offenders will be slapped a fine of Rs 25,000. Subsequent violations would attract fines of Rs 50,000 and Rs 1 lakh. The offenders might even face a jail term of six to 12 months.All food items and beverages sold in single-screen cinema halls and in multiplexes should prominently display prices and quantities on the products. The prices should be the same as the prices of the products sold outside the theatres. The department will launch a special drive in theatres in Hyderabad on August 2 and 3 to see whether the rules are adhered to or not.The department has sent notices to the theatre managements, asking them to conform to the new rules from August 1. While the shops in the theatres are allowed to print stickers on the packets (other than the branded goods) till August 30, beginning September 1, they should have the details printed on the product wrappers.The details should include the price, name of the product, weight, manufacturer and customer care contact information. Legal Metrology Controller, Akun Sabharwal, held a meeting on Sunday with department officials from all the districts on the issue. “If there is a change in the price of the product, it should be corrected as and when the change happens,” a department official said.Aggrieved consumers can lodge complaints at 180042500333, or through WhatsApp at 7330774444. The managements have been asked to display these numbers prominently in the theatres.center_img Published on Telangana SHARE SHARE EMAIL COMMENTSlast_img read more

CONTINUE READING